FOXO3a (Forkhead Transcription Factor O Subfamily Member 3a) Links Vascular Smooth Muscle Cell Apoptosis, Matrix Breakdown, Atherosclerosis, and Vascular Remodeling Through a Novel Pathway Involving MMP13 (Matrix Metalloproteinase 13)

OBJECTIVE—: Vascular smooth muscle cell (VSMC) apoptosis accelerates atherosclerosis and promotes breakdown of the extracellular matrix, but the mechanistic links between these 2 processes are unknown. The forkhead protein FOXO3a (forkhead transcription factor O subfamily member 3a) is activated in...

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Publicado en:Arterioscler Thromb Vasc Biol
Autores principales: Yu, Haixiang, Fellows, Adam, Foote, Kirsty, Yang, Zhaoqing, Figg, Nichola, Littlewood, Trevor, Bennett, Martin
Formato: Artigo
Lenguaje:Inglês
Publicado: Lippincott Williams & Wilkins 2018
Materias:
Basic Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828387/
https://ncbi.nlm.nih.gov/pubmed/29326312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.117.310502
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