14-3-3 Protein Masks the DNA Binding Interface of Forkhead Transcription Factor FOXO4

The role of 14-3-3 proteins in the regulation of FOXO forkhead transcription factors is at least 2-fold. First, the 14-3-3 binding inhibits the interaction between the FOXO and the target DNA. Second, the 14-3-3 proteins prevent nuclear reimport of FOXO factors by masking their nuclear localization...

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Bibliographic Details
Main Authors: Silhan, Jan, Vacha, Petr, Strnadova, Pavla, Vecer, Jaroslav, Herman, Petr, Sulc, Miroslav, Teisinger, Jan, Obsilova, Veronika, Obsil, Tomas
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740560/
https://ncbi.nlm.nih.gov/pubmed/19416966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.002725
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