Indoxyl Sulfate Upregulates Liver P-Glycoprotein Expression and Activity through Aryl Hydrocarbon Receptor Signaling

In patients with CKD, not only renal but also, nonrenal clearance of drugs is altered. Uremic toxins could modify the expression and/or activity of drug transporters in the liver. We tested whether the uremic toxin indoxyl sulfate (IS), an endogenous ligand of the transcription factor aryl hydrocarb...

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Pubblicato in:J Am Soc Nephrol
Autori principali: Santana Machado, Tacy, Poitevin, Stéphane, Paul, Pascale, McKay, Nathalie, Jourde-Chiche, Noémie, Legris, Tristan, Mouly-Bandini, Annick, Dignat-George, Françoise, Brunet, Philippe, Masereeuw, Rosalinde, Burtey, Stéphane, Cerini, Claire
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2018
Soggetti:
Basic Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5827590/
https://ncbi.nlm.nih.gov/pubmed/29222397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2017030361
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