Indoxyl Sulfate Upregulates Liver P-Glycoprotein Expression and Activity through Aryl Hydrocarbon Receptor Signaling

In patients with CKD, not only renal but also, nonrenal clearance of drugs is altered. Uremic toxins could modify the expression and/or activity of drug transporters in the liver. We tested whether the uremic toxin indoxyl sulfate (IS), an endogenous ligand of the transcription factor aryl hydrocarb...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Santana Machado, Tacy, Poitevin, Stéphane, Paul, Pascale, McKay, Nathalie, Jourde-Chiche, Noémie, Legris, Tristan, Mouly-Bandini, Annick, Dignat-George, Françoise, Brunet, Philippe, Masereeuw, Rosalinde, Burtey, Stéphane, Cerini, Claire
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2018
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5827590/
https://ncbi.nlm.nih.gov/pubmed/29222397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2017030361
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