ApoL1 Overexpression Drives Variant-Independent Cytotoxicity

Coding variants in the APOL1 gene are associated with kidney diseases in African ancestral populations; yet, the underlying biologic mechanisms remain uncertain. Variant-dependent autophagic and cytotoxic cell death have been proposed as pathogenic pathways mediating kidney injury. To examine this p...

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Veröffentlicht in:J Am Soc Nephrol
Hauptverfasser: O'Toole, John F., Schilling, William, Kunze, Diana, Madhavan, Sethu M., Konieczkowski, Martha, Gu, Yaping, Luo, Liping, Wu, Zhenzhen, Bruggeman, Leslie A., Sedor, John R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Nephrology 2018
Schlagworte:
Basic Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5827587/
https://ncbi.nlm.nih.gov/pubmed/29180397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2016121322
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