Chronic liver injury alters driver mutation profiles in hepatocellular carcinoma

Most hepatocellular carcinomas (HCCs) develop in a chronically injured liver, yet the extent to which this microenvironment promotes neoplastic transformation or influences selective pressures for genetic drivers of HCC remains unclear. We sought to determine the impact of hepatic injury in an estab...

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Bibliographic Details
Published in:Hepatology
Main Authors: Riordan, Jesse D., Feddersen, Charlotte R., Tschida, Barbara R., Jackson, Pauline, Keng, Vincent W., Linden, Michael A., Amin, Khalid, Stipp, Christopher S., Largaespada, David A., Dupuy, Adam J.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5826818/
https://ncbi.nlm.nih.gov/pubmed/28961327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29565
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