The mTOR-S6K Pathway Links Growth Signaling to DNA Damage Response by Targeting RNF168

Growth signals, such as extracellular nutrients and growth factors, have significant impacts on genome integrity, while the direct underlying link remains unclear. Here we show that the mechanistic target of rapamycin (mTOR)-ribosomal S6 kinase (S6K) pathway, a central regulator of growth signaling,...

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Publicado no:Nat Cell Biol
Main Authors: Xie, Xiaoduo, Hu, Hongli, Tong, Xinyuan, Li, Long, Liu, Xiangyuan, Chen, Min, Yuan, Huairui, Xie, Xia, Li, Qingrun, Zhang, Yuxue, Ouyang, Huafang, Wei, Mengqi, Huang, Jing, Liu, Pengda, Gan, Wenjian, Liu, Yong, Xie, Anyong, Kuai, Xiaoling, Chirn, Gung-Wei, Zhou, Hu, Zeng, Rong, Hu, Ronggui, Qin, Jun, Meng, Fei-Long, Wei, Wenyi, Ji, Hongbin, Gao, Daming
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5826806/
https://ncbi.nlm.nih.gov/pubmed/29403037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-017-0033-8
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