The mTOR-S6K Pathway Links Growth Signaling to DNA Damage Response by Targeting RNF168

Growth signals, such as extracellular nutrients and growth factors, have significant impacts on genome integrity, while the direct underlying link remains unclear. Here we show that the mechanistic target of rapamycin (mTOR)-ribosomal S6 kinase (S6K) pathway, a central regulator of growth signaling,...

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Detaylı Bibliyografya
Yayımlandı:Nat Cell Biol
Asıl Yazarlar: Xie, Xiaoduo, Hu, Hongli, Tong, Xinyuan, Li, Long, Liu, Xiangyuan, Chen, Min, Yuan, Huairui, Xie, Xia, Li, Qingrun, Zhang, Yuxue, Ouyang, Huafang, Wei, Mengqi, Huang, Jing, Liu, Pengda, Gan, Wenjian, Liu, Yong, Xie, Anyong, Kuai, Xiaoling, Chirn, Gung-Wei, Zhou, Hu, Zeng, Rong, Hu, Ronggui, Qin, Jun, Meng, Fei-Long, Wei, Wenyi, Ji, Hongbin, Gao, Daming
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5826806/
https://ncbi.nlm.nih.gov/pubmed/29403037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-017-0033-8
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