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Polymerization of hexamethylene diisocyanate in solution and a 260.23 m/z [M+H](+) ion in exposed human cells

Hexamethylene diisocyanate (HDI) is an important industrial chemical that can cause asthma, however pathogenic mechanisms remain unclear. Upon entry into the respiratory tract, HDI’s N=C=O groups may undergo nucleophilic addition (conjugate) to host molecules (e.g. proteins), or instead react with w...

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Detalhes bibliográficos
Publicado no:Anal Biochem
Main Authors: Wisnewski, Adam V, Liu, Jian, Redlich, Carrie A, Nassar, Ala F
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5826792/
https://ncbi.nlm.nih.gov/pubmed/29175138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2017.11.017
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