Enantioselective Total Synthesis of Antibiotic CJ-16,264, Synthesis and Biological Evaluation of Designed Analogues, and Discovery of Highly Potent and Simpler Antibacterial Agents

An improved and enantioselective total synthesis of antibiotic CJ-16,264 through a practical kinetic resolution and an iodolactonization reaction to form the iodo pyrrolizidinone fragment of the molecule is described. A series of racemic and enantiopure analogues of CJ-16,264 was designed and synthe...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Nicolaou, K. C., Pulukuri, Kiran Kumar, Rigol, Stephan, Buchman, Marek, Shah, Akshay A., Cen, Nicholas, McCurry, Megan D., Beabout, Kathryn, Shamoo, Yousif
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5826612/
https://ncbi.nlm.nih.gov/pubmed/29064688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b08749
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