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Total Synthesis and Structural Revision of Antibiotic CJ-16,264()

The total synthesis and structural revision of antibiotic CJ-16,264 is described. Starting with citronellal, the quest for the target molecule featured a novel bis-transannular Diels–Alder reaction that casted stereoselectively the decalin system and included the synthesis of six isomers before demy...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Nicolaou, K. C., Shah, Akshay A., Korman, Henry, Khan, Tabrez, Shi, Lei, Worawalai, Wisuttaya, Theodorakis, Emmanuel A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4530996/
https://ncbi.nlm.nih.gov/pubmed/26096055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201504337
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