HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis

HuR is an RNA-binding protein implicated in immune homeostasis and various cancers, including colorectal cancer. HuR binding to AU-rich elements within the 3′ untranslated region of mRNAs encoding oncogenes, growth factors, and various cytokines leads message stability and translation. In this study...

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Pubblicato in:Cancer Res
Autori principali: Lang, Michaela, Berry, David, Passecker, Katharina, Mesteri, Ildiko, Bhuju, Sabin, Ebner, Florian, Sedlyarov, Vitaly, Evstatiev, Rayko, Dammann, Kyle, Loy, Alexander, Kuzyk, Orest, Kovarik, Pavel, Khare, Vineeta, Beibel, Martin, Roma, Guglielmo, Meisner-Kober, Nicole, Gasche, Christoph
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5826591/
https://ncbi.nlm.nih.gov/pubmed/28428272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1726
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