PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation

P21-activated kinases (PAKs) are multifunctional effectors of Rho GTPases with both kinase and scaffolding activity. Here, we investigated the effects of inflammation on PAK1 signaling and its role in colitis-driven carcinogenesis. PAK1 and p-PAK1 (Thr423) were assessed by immunohistochemistry, immu...

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Detalhes bibliográficos
Publicado no:Biochim Biophys Acta
Main Authors: Dammann, Kyle, Khare, Vineeta, Lang, Michaela, Claudel, Thierry, Harpain, Felix, Granofszky, Nicolas, Evstatiev, Rayko, Williams, Jonathan M., Pritchard, D. Mark, Watson, Alastair, Gasche, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Pub. Co 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576212/
https://ncbi.nlm.nih.gov/pubmed/26036343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2015.05.031
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