Relation between Skin Pharmacokinetics and Efficacy in AmBisome Treatment of Murine Cutaneous Leishmaniasis

AmBisome (LAmB), a liposomal formulation of amphotericin B (AmB), is a second-line treatment for the parasitic skin disease cutaneous leishmaniasis (CL). Little is known about its tissue distribution and pharmacodynamics to inform clinical use in CL. Here, we compared the skin pharmacokinetics of LA...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Wijnant, Gert-Jan, Van Bocxlaer, Katrien, Yardley, Vanessa, Harris, Andy, Murdan, Sudaxshina, Croft, Simon L.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2018
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5826151/
https://ncbi.nlm.nih.gov/pubmed/29263075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02009-17
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