Pharmacokinetics and Pharmacodynamics of the Nitroimidazole DNDI-0690 in Mouse Models of Cutaneous Leishmaniasis

The nitroimidazole DNDI-0690 is a clinical drug candidate for visceral leishmaniasis (VL) that also shows potent in vitro and in vivo activity against cutaneous leishmaniasis (CL). To support further development of this compound into a patient-friendly oral or topical formulation for the treatment o...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Wijnant, Gert-Jan, Croft, Simon L., de la Flor, Raul, Alavijeh, Mo, Yardley, Vanessa, Braillard, Stéphanie, Mowbray, Charles, Van Bocxlaer, Katrien
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2019
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709472/
https://ncbi.nlm.nih.gov/pubmed/31262757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00829-19
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