Local Skin Inflammation in Cutaneous Leishmaniasis as a Source of Variable Pharmacokinetics and Therapeutic Efficacy of Liposomal Amphotericin B

Disfiguring skin lesions caused by several species of the Leishmania parasite characterize cutaneous leishmaniasis (CL). Successful treatment of CL with intravenous (i.v.) liposomal amphotericin B (LAmB) relies on the presence of adequate antibiotic concentrations at the dermal site of infection wit...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Wijnant, Gert-Jan, Van Bocxlaer, Katrien, Fortes Francisco, Amanda, Yardley, Vanessa, Harris, Andy, Alavijeh, Mo, Murdan, Sudaxshina, Croft, Simon L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2018
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6153808/
https://ncbi.nlm.nih.gov/pubmed/30082295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00631-18
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