Effects of Renal Impairment and Hemodialysis on the Pharmacokinetics and Safety of the Glecaprevir and Pibrentasvir Combination in Hepatitis C Virus-Negative Subjects

Hepatitis C virus (HCV) infection is an independent risk factor for developing chronic renal impairment and end-stage renal disease. Limited treatment options are available for HCV genotype 2, 3, 5, and 6 infections in patients with an estimated glomerular filtration rate (eGFR) of <30 ml/min. Gl...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Kosloski, Matthew P., Zhao, Weihan, Marbury, Thomas C., Preston, Richard A., Collins, Michael G., Pugatch, David, Mensa, Federico, Kort, Jens, Liu, Wei
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2018
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5826128/
https://ncbi.nlm.nih.gov/pubmed/29263061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01990-17
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