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Blood vitronectin is a major activator of LIF and IL-6 in the brain through integrin–FAK and uPAR signaling
We defined how blood-derived vitronectin (VTN) rapidly and potently activates leukemia inhibitory factor (LIF) and pro-inflammatory interleukin 6 (IL-6) in vitro and after vascular injury in the brain. Treatment with VTN (but not fibrinogen, fibronectin, laminin-111 or collagen-I) substantially incr...
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| Pubblicato in: | J Cell Sci |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Company of Biologists Ltd
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5826040/ https://ncbi.nlm.nih.gov/pubmed/29222114 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.202580 |
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