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Blood vitronectin is a major activator of LIF and IL-6 in the brain through integrin–FAK and uPAR signaling
We defined how blood-derived vitronectin (VTN) rapidly and potently activates leukemia inhibitory factor (LIF) and pro-inflammatory interleukin 6 (IL-6) in vitro and after vascular injury in the brain. Treatment with VTN (but not fibrinogen, fibronectin, laminin-111 or collagen-I) substantially incr...
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| Publicado no: | J Cell Sci |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Company of Biologists Ltd
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5826040/ https://ncbi.nlm.nih.gov/pubmed/29222114 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.202580 |
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