Mms19 is a mitotic gene that permits Cdk7 to be fully active as a Cdk-activating kinase

Mms19 encodes a cytosolic iron-sulphur assembly component. We found that Drosophila Mms19 is also essential for mitotic divisions and for the proliferation of diploid cells. Reduced Mms19 activity causes severe mitotic defects in spindle dynamics and chromosome segregation, and loss of zygotic Mms19...

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Vydáno v:Development
Hlavní autoři: Nag, Rishita Narendra, Niggli, Selina, Sousa-Guimarães, Sofia, Vazquez-Pianzola, Paula, Suter, Beat
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists Ltd 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5825849/
https://ncbi.nlm.nih.gov/pubmed/29361561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.156802
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