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CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translation

Mitosis is commonly thought to be associated with reduced cap-dependent protein translation. Here we show an alternative control mechanism for maintaining cap-dependent translation during mitosis revealed by a viral oncoprotein, Merkel cell polyomavirus small T (MCV sT). We find MCV sT to be a promi...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Shuda, Masahiro, Velásquez, Celestino, Cheng, Erdong, Cordek, Daniel G., Kwun, Hyun Jin, Chang, Yuan, Moore, Patrick S.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4434708/
https://ncbi.nlm.nih.gov/pubmed/25883264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1505787112
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