Proton‐independent activation of acid‐sensing ion channel 3 by an alkaloid, lindoldhamine, from Laurus nobilis

BACKGROUND AND PURPOSE: Acid‐sensing ion channels (ASICs) play an important role in synaptic plasticity and learning, as well as in nociception and mechanosensation. ASICs are involved in pain and in neurological and psychiatric diseases, but their therapeutic potential is limited by the lack of lig...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Osmakov, Dmitry I, Koshelev, Sergey G, Andreev, Yaroslav A, Dubinnyi, Maxim A, Kublitski, Vadim S, Efremov, Roman G, Sobolevsky, Alexander I, Kozlov, Sergey A
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5825300/
https://ncbi.nlm.nih.gov/pubmed/29277899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14134
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