Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients

Fetal hemoglobin (HbF) level has emerged as an important prognostic factor in sickle-cell disease (SCD) and can be measured by the proportion of HbF-containing erythrocytes (F-cells). Recently, BCL11A (zinc-finger protein) was identified as a regulator of HbF, and the strongest association signals w...

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Опубликовано в: :J Hum Genet
Главные авторы: Bhatnagar, Pallav, Purvis, Shirley, Barron-Casella, Emily, DeBaun, Michael R, Casella, James F, Arking, Dan E, Keefer, Jeffrey R
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5825003/
https://ncbi.nlm.nih.gov/pubmed/21326311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jhg.2011.12
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