A Genome-Wide Association Study of Total Bilirubin and Cholelithiasis Risk in Sickle Cell Anemia

Serum bilirubin levels have been associated with polymorphisms in the UGT1A1 promoter in normal populations and in patients with hemolytic anemias, including sickle cell anemia. When hemolysis occurs circulating heme increases, leading to elevated bilirubin levels and an increased incidence of chole...

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Main Authors: Milton, Jacqueline N., Sebastiani, Paola, Solovieff, Nadia, Hartley, Stephen W., Bhatnagar, Pallav, Arking, Dan E., Dworkis, Daniel A., Casella, James F., Barron-Casella, Emily, Bean, Christopher J., Hooper, W. Craig, DeBaun, Michael R., Garrett, Melanie E., Soldano, Karen, Telen, Marilyn J., Ashley-Koch, Allison, Gladwin, Mark T., Baldwin, Clinton T., Steinberg, Martin H., Klings, Elizabeth S.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338756/
https://ncbi.nlm.nih.gov/pubmed/22558097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034741
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