STAT3/p53 pathway activation disrupts IFN-β–induced dormancy in tumor-repopulating cells

Dynamic interaction with the immune system profoundly regulates tumor cell dormancy. However, it is unclear how immunological cues trigger cancer cell–intrinsic signaling pathways for entering into dormancy. Here, we show that IFN-β treatment induced tumor-repopulating cells (TRC) to enter dormancy...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Liu, Yuying, Lv, Jiadi, Liu, Jinyan, Liang, Xiaoyu, Jin, Xun, Xie, Jing, Zhang, Le, Chen, Degao, Fiskesund, Roland, Tang, Ke, Ma, Jingwei, Zhang, Huafeng, Dong, Wenqian, Mo, Siqi, Zhang, Tianzhen, Cheng, Feiran, Zhou, Yabo, Jia, Qingzhu, Zhu, Bo, Kong, Yan, Guo, Jun, Zhang, Haizeng, Hu, Zhuo-Wei, Cao, Xuetao, Qin, F. Xiao-Feng, Huang, Bo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5824876/
https://ncbi.nlm.nih.gov/pubmed/29431732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI96329
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