STAT3/p53 pathway activation disrupts IFN-β–induced dormancy in tumor-repopulating cells

Dynamic interaction with the immune system profoundly regulates tumor cell dormancy. However, it is unclear how immunological cues trigger cancer cell–intrinsic signaling pathways for entering into dormancy. Here, we show that IFN-β treatment induced tumor-repopulating cells (TRC) to enter dormancy...

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Vydáno v:J Clin Invest
Hlavní autoři: Liu, Yuying, Lv, Jiadi, Liu, Jinyan, Liang, Xiaoyu, Jin, Xun, Xie, Jing, Zhang, Le, Chen, Degao, Fiskesund, Roland, Tang, Ke, Ma, Jingwei, Zhang, Huafeng, Dong, Wenqian, Mo, Siqi, Zhang, Tianzhen, Cheng, Feiran, Zhou, Yabo, Jia, Qingzhu, Zhu, Bo, Kong, Yan, Guo, Jun, Zhang, Haizeng, Hu, Zhuo-Wei, Cao, Xuetao, Qin, F. Xiao-Feng, Huang, Bo
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5824876/
https://ncbi.nlm.nih.gov/pubmed/29431732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI96329
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