STAT3/p53 pathway activation disrupts IFN-β–induced dormancy in tumor-repopulating cells

Dynamic interaction with the immune system profoundly regulates tumor cell dormancy. However, it is unclear how immunological cues trigger cancer cell–intrinsic signaling pathways for entering into dormancy. Here, we show that IFN-β treatment induced tumor-repopulating cells (TRC) to enter dormancy...

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Bibliografske podrobnosti
izdano v:J Clin Invest
Main Authors: Liu, Yuying, Lv, Jiadi, Liu, Jinyan, Liang, Xiaoyu, Jin, Xun, Xie, Jing, Zhang, Le, Chen, Degao, Fiskesund, Roland, Tang, Ke, Ma, Jingwei, Zhang, Huafeng, Dong, Wenqian, Mo, Siqi, Zhang, Tianzhen, Cheng, Feiran, Zhou, Yabo, Jia, Qingzhu, Zhu, Bo, Kong, Yan, Guo, Jun, Zhang, Haizeng, Hu, Zhuo-Wei, Cao, Xuetao, Qin, F. Xiao-Feng, Huang, Bo
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2018
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5824876/
https://ncbi.nlm.nih.gov/pubmed/29431732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI96329
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