Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells

Interactions with the immune system may lead tumorigenic cells into dormancy. However, the underlying molecular mechanism is poorly understood. Using a 3D fibrin gel model, we show that IFN-γ induces tumour-repopulating cells (TRCs) to enter dormancy through an indolamine 2,3-dioxygenase 1 (IDO1)-ky...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Liu, Yuying, Liang, Xiaoyu, Yin, Xiaonan, Lv, Jiadi, Tang, Ke, Ma, Jingwei, Ji, Tiantian, Zhang, Huafeng, Dong, Wenqian, Jin, Xun, Chen, Degao, Li, Yanchun, Zhang, Songyan, Xie, Heidi Q., Zhao, Bin, Zhao, Tong, Lu, Jinzhi, Hu, Zhuo-Wei, Cao, Xuetao, Qin, F. Xiao-Feng, Huang, Bo
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2017
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5436221/
https://ncbi.nlm.nih.gov/pubmed/28488695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15207
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires