Hypothalamic loss of Snord116 recapitulates the hyperphagia of Prader-Willi syndrome

Profound hyperphagia is a major disabling feature of Prader-Willi syndrome (PWS). Characterization of the mechanisms that underlie PWS-associated hyperphagia has been slowed by the paucity of animal models with increased food intake or obesity. Mice with a microdeletion encompassing the Snord116 clu...

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Pubblicato in:J Clin Invest
Autori principali: Polex-Wolf, Joseph, Lam, Brian Y.H., Larder, Rachel, Tadross, John, Rimmington, Debra, Bosch, Fàtima, Cenzano, Verónica Jiménez, Ayuso, Eduard, Ma, Marcella K.L., Rainbow, Kara, Coll, Anthony P., O’Rahilly, Stephen, Yeo, Giles S.H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5824864/
https://ncbi.nlm.nih.gov/pubmed/29376887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI97007
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