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Examining tRNA 3′-ends in Escherichia coli: teamwork between CCA-adding enzyme, RNase T, and RNase R

tRNA maturation and quality control are crucial for proper functioning of these transcripts in translation. In several organisms, defective tRNAs were shown to be tagged by poly(A) or CCACCA tails and subsequently degraded by 3′-exonucleases. In a deep-sequencing analysis of tRNA 3′-ends, we detecte...

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Pubblicato in:RNA
Autori principali: Wellner, Karolin, Czech, Andreas, Ignatova, Zoya, Betat, Heike, Mörl, Mario
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5824355/
https://ncbi.nlm.nih.gov/pubmed/29180590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.064436.117
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