Structure-function analysis of ferroportin defines the binding site and an alternative mechanism of action of hepcidin

Nonclassical ferroportin disease (FD) is a form of hereditary hemochromatosis caused by mutations in the iron transporter ferroportin (Fpn), resulting in parenchymal iron overload. Fpn is regulated by the hormone hepcidin, which induces Fpn endocytosis and cellular iron retention. We characterized 1...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Aschemeyer, Sharraya, Qiao, Bo, Stefanova, Deborah, Valore, Erika V., Sek, Albert C., Ruwe, T. Alex, Vieth, Kyle R., Jung, Grace, Casu, Carla, Rivella, Stefano, Jormakka, Mika, Mackenzie, Bryan, Ganz, Tomas, Nemeth, Elizabeta
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Red Cells, Iron, and Erythropoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5824336/
https://ncbi.nlm.nih.gov/pubmed/29237594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-05-786590
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