Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246

TP53 mutants (mutp53) are involved in the pathogenesis of most human cancers. Specific mutp53 proteins gain oncogenic functions (GOFs) distinct from the tumor suppressor activity of the wild-type protein. Tumor-associated macrophages (TAMs), a hallmark of solid tumors, are typically correlated with...

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Udgivet i:Nat Commun
Main Authors: Cooks, Tomer, Pateras, Ioannis S., Jenkins, Lisa M., Patel, Keval M., Robles, Ana I., Morris, James, Forshew, Tim, Appella, Ettore, Gorgoulis, Vassilis G., Harris, Curtis C.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5823939/
https://ncbi.nlm.nih.gov/pubmed/29472616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03224-w
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