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p53 Mutations and Inflammation-Associated Cancer Are Linked through TNF Signaling
In this issue, Di Minin et al. (2014) link mutant p53 and chronic inflammation to tumorigenic progression via TNF signaling. Mirtp53 interacts with the tumor suppressor DAB2IP in the cytoplasm, and induces a TNF-dependent transcriptional profile via NF-kB and JNK.
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| Publicado en: | Mol Cell |
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| Autores principales: | , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6333310/ https://ncbi.nlm.nih.gov/pubmed/25479634 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.11.018 |
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