EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase

Ciliogenesis is generally inhibited in dividing cells, however, it has been unclear which signaling cascades regulate the phenomenon. Here, we report that epidermal growth factor receptor (EGFR) kinase suppresses ciliogenesis by directly phosphorylating the deubiquitinase USP8 on Tyr-717 and Tyr-810...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Kasahara, Kousuke, Aoki, Hiromasa, Kiyono, Tohru, Wang, Shujie, Kagiwada, Harumi, Yuge, Mizuki, Tanaka, Toshio, Nishimura, Yuhei, Mizoguchi, Akira, Goshima, Naoki, Inagaki, Masaki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5823934/
https://ncbi.nlm.nih.gov/pubmed/29472535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03117-y
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