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EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase
Ciliogenesis is generally inhibited in dividing cells, however, it has been unclear which signaling cascades regulate the phenomenon. Here, we report that epidermal growth factor receptor (EGFR) kinase suppresses ciliogenesis by directly phosphorylating the deubiquitinase USP8 on Tyr-717 and Tyr-810...
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| 出版年: | Nat Commun |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5823934/ https://ncbi.nlm.nih.gov/pubmed/29472535 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03117-y |
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