HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR130

Checkpoint kinases sense replicative stress to prevent DNA damage. Here we show that the histone deacetylases HDAC1/HDAC2 sustain the phosphorylation of the checkpoint kinases ATM, CHK1 and CHK2, activity of the cell cycle gatekeeper kinases WEE1 and CDK1, and induction of the tumour suppressor p53...

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Udgivet i:Nat Commun
Main Authors: Göder, Anja, Emmerich, Claudia, Nikolova, Teodora, Kiweler, Nicole, Schreiber, Maria, Kühl, Toni, Imhof, Diana, Christmann, Markus, Heinzel, Thorsten, Schneider, Günter, Krämer, Oliver H.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5823910/
https://ncbi.nlm.nih.gov/pubmed/29472538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03096-0
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