Lack of galectin-3 modifies differentially Notch ligands in bone marrow and spleen stromal cells interfering with B cell differentiation

Galectin-3 (Gal-3) is a β-galactoside binding protein that controls cell-cell and cell-extracellular matrix interactions. In lymphoid organs, gal-3 inhibits B cell differentiation by mechanisms poorly understood. The B cell development is dependent on tissue organization and stromal cell signaling,...

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Publicat a:Sci Rep
Autors principals: de Oliveira, Felipe Leite, dos Santos, Sofia Nascimento, Ricon, Lauremilia, da Costa, Thayse Pinheiro, Pereira, Jonathas Xavier, Brand, Camila, Fermino, Marise Lopes, Chammas, Roger, Bernardes, Emerson Soares, El-Cheikh, Márcia Cury
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5823902/
https://ncbi.nlm.nih.gov/pubmed/29472568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-21409-7
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