Galectin-3 acts as an angiogenic switch to induce tumor angiogenesis via Jagged-1/Notch activation

Angiogenesis is a coordinated process tightly regulated by the balance between Delta-like-4 (DLL4) and Jagged-1 (JAG1) in endothelial cells. Here we show that galectin-3 (gal-3), a glycan-binding protein secreted by cancer cells under hypoxic conditions, triggers sprouting angiogenesis, assisted by...

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Vydáno v:Oncotarget
Hlavní autoři: dos Santos, Sofia Nascimento, Sheldon, Helen, Pereira, Jonathas Xavier, Paluch, Christopher, Bridges, Esther M, El-Cheikh, Márcia Curry, Harris, Adrian L, Bernardes, Emerson Soares
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5564783/
https://ncbi.nlm.nih.gov/pubmed/28533486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17718
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