Novel Combination BMP7 and HGF Gene Therapy Instigates Selective Myofibroblast Apoptosis and Reduces Corneal Haze In Vivo

PURPOSE: We tested the potential of bone morphogenic protein 7 (BMP7) and hepatocyte growth factor (HGF) combination gene therapy to treat preformed corneal fibrosis using established rabbit in vivo and human in vitro models. METHODS: Eighteen New Zealand White rabbits were used. Corneal fibrosis wa...

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Detalhes bibliográficos
Publicado no:Invest Ophthalmol Vis Sci
Main Authors: Gupta, Suneel, Fink, Michael K., Ghosh, Arkasubhra, Tripathi, Ratnakar, Sinha, Prashant R., Sharma, Ajay, Hesemann, Nathan P., Chaurasia, Shyam S., Giuliano, Elizabeth A., Mohan, Rajiv R.
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2018
Assuntos:
Cornea
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5822743/
https://ncbi.nlm.nih.gov/pubmed/29490341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.17-23308
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