Targeted AAV5-Smad7 gene therapy inhibits corneal scarring in vivo

Corneal scarring is due to aberrant activity of the transforming growth factor β (TGFβ) signaling pathway following traumatic, mechanical, infectious, or surgical injury. Altered TGFβ signaling cascade leads to downstream Smad (Suppressor of mothers against decapentaplegic) protein-mediated signalin...

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Udgivet i:PLoS One
Main Authors: Gupta, Suneel, Rodier, Jason T., Sharma, Ajay, Giuliano, Elizabeth A., Sinha, Prashant R., Hesemann, Nathan P., Ghosh, Arkasubhra, Mohan, Rajiv R.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5365107/
https://ncbi.nlm.nih.gov/pubmed/28339457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0172928
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