[(18)F]FSPG-PET reveals increased cystine/glutamate antiporter (xc-) activity in a mouse model of multiple sclerosis

BACKGROUND: The cystine/glutamate antiporter (xc-) has been implicated in several neurological disorders and, specifically, in multiple sclerosis (MS) as a mediator of glutamate excitotoxicity and proinflammatory immune responses. We aimed to evaluate an xc-specific positron emission tomography (PET...

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Foilsithe in:J Neuroinflammation
Main Authors: Hoehne, Aileen, James, Michelle L., Alam, Israt S., Ronald, John A., Schneider, Bernadette, D’Souza, Aloma, Witney, Timothy H., Andrews, Lauren E., Cropper, Haley C., Behera, Deepak, Gowrishankar, Gayatri, Ding, Zhaoqing, Wyss-Coray, Tony, Chin, Frederick T., Biswal, Sandip, Gambhir, Sanjiv S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2018
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5822551/
https://ncbi.nlm.nih.gov/pubmed/29471880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1080-1
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