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P49 SENSITIZING GLIOBLASTOMA CELLS TO THERAPY BY TARGETING THE L-GLUTAMATE/L-CYSTINE ANTIPORTER SYSTEM XC-
INTRODUCTION: System xc-(SXC),a L-cystine/L-glutamate antiporter represents the primary non-vesicular route of glutamate release. Certain cancers,such as Glioblastoma multiforme(GBM),are unable to synthesise sufficient concentrations of L-cysteine,rendering them dependent on L-cystine influx via SXC...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4200916/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou249.37 |
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