P49 SENSITIZING GLIOBLASTOMA CELLS TO THERAPY BY TARGETING THE L-GLUTAMATE/L-CYSTINE ANTIPORTER SYSTEM XC-

INTRODUCTION: System xc-(SXC),a L-cystine/L-glutamate antiporter represents the primary non-vesicular route of glutamate release. Certain cancers,such as Glioblastoma multiforme(GBM),are unable to synthesise sufficient concentrations of L-cysteine,rendering them dependent on L-cystine influx via SXC...

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Detaylı Bibliyografya
Asıl Yazarlar: Kolb, Anna, Piccirillo, Sara, Watts, Colin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2014
Konular:
Abstracts
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200916/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou249.37
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