Dissection of affinity captured LINE-1 macromolecular complexes

Long Interspersed Nuclear Element-1 (LINE-1, L1) is a mobile genetic element active in human genomes. L1-encoded ORF1 and ORF2 proteins bind L1 RNAs, forming ribonucleoproteins (RNPs). These RNPs interact with diverse host proteins, some repressive and others required for the L1 lifecycle. Using dif...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Taylor, Martin S, Altukhov, Ilya, Molloy, Kelly R, Mita, Paolo, Jiang, Hua, Adney, Emily M, Wudzinska, Aleksandra, Badri, Sana, Ischenko, Dmitry, Eng, George, Burns, Kathleen H, Fenyö, David, Chait, Brian T, Alexeev, Dmitry, Rout, Michael P, Boeke, Jef D, LaCava, John
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Biochemistry and Chemical Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5821459/
https://ncbi.nlm.nih.gov/pubmed/29309035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.30094
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