Cholinergic signaling mediates the effects of xenin-25 on secretion of pancreatic polypeptide but not insulin or glucagon in humans with impaired glucose tolerance

We previously demonstrated that infusion of an intestinal peptide called xenin-25 (Xen) amplifies the effects of glucose-dependent insulinotropic polypeptide (GIP) on insulin secretion rates (ISRs) and plasma glucagon levels in humans. However, these effects of Xen, but not GIP, were blunted in huma...

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Pubblicato in:PLoS One
Autori principali: Wang, Songyan, Oestricker, Lauren Z., Wallendorf, Michael J., Sterl, Karin, Dunai, Judit, Kilpatrick, C. Rachel, Patterson, Bruce W., Reeds, Dominic N., Wice, Burton M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5821323/
https://ncbi.nlm.nih.gov/pubmed/29466430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0192441
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