Xenin-25 Amplifies GIP-Mediated Insulin Secretion in Humans With Normal and Impaired Glucose Tolerance but Not Type 2 Diabetes

Glucose-dependent insulinotropic polypeptide (GIP) potentiates glucose-stimulated insulin secretion (GSIS). This response is blunted in type 2 diabetes (T2DM). Xenin-25 is a 25–amino acid neurotensin-related peptide that amplifies GIP-mediated GSIS in hyperglycemic mice. This study determines if xen...

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Détails bibliographiques
Auteurs principaux: Wice, Burton M., Reeds, Dominic N., Tran, Hung D., Crimmins, Dan L., Patterson, Bruce W., Dunai, Judit, Wallendorf, Michael J., Ladenson, Jack H., Villareal, Dennis T., Polonsky, Kenneth S.
Format: Artigo
Langue:Inglês
Publié: American Diabetes Association 2012
Sujets:
Pathophysiology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3379667/
https://ncbi.nlm.nih.gov/pubmed/22522617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1451
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