The homozygous CX3CR1-M280 mutation impairs human monocyte survival

Several reports have demonstrated that mouse Cx3cr1 signaling promotes monocyte/macrophage survival. In agreement, we previously found that, in a mouse model of systemic candidiasis, genetic deficiency of Cx3cr1 resulted in increased mortality and impaired tissue fungal clearance associated with dec...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Collar, Amanda L., Swamydas, Muthulekha, O’Hayre, Morgan, Sajib, Md Sanaullah, Hoffman, Kevin W., Singh, Satya P., Mourad, Ahmad, Johnson, Melissa D., Ferre, Elise M.N., Farber, Joshua M., Lim, Jean K., Mikelis, Constantinos M., Gutkind, J. Silvio, Lionakis, Michail S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5821174/
https://ncbi.nlm.nih.gov/pubmed/29415879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.95417
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