CX(3)CR1-dependent renal macrophage survival promotes Candida control and host survival

Systemic Candida albicans infection causes high morbidity and mortality and is associated with neutropenia; however, the roles of other innate immune cells in pathogenesis are poorly defined. Here, using a mouse model of systemic candidiasis, we found that resident macrophages accumulated in the kid...

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Main Authors: Lionakis, Michail S., Swamydas, Muthulekha, Fischer, Brett G., Plantinga, Theo S., Johnson, Melissa D., Jaeger, Martin, Green, Nathaniel M., Masedunskas, Andrius, Weigert, Roberto, Mikelis, Constantinos, Wan, Wuzhou, Lee, Chyi-Chia Richard, Lim, Jean K., Rivollier, Aymeric, Yang, John C., Laird, Greg M., Wheeler, Robert T., Alexander, Barbara D., Perfect, John R., Gao, Ji-Liang, Kullberg, Bart-Jan, Netea, Mihai G., Murphy, Philip M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3859390/
https://ncbi.nlm.nih.gov/pubmed/24177428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI71307
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