The homozygous CX3CR1-M280 mutation impairs human monocyte survival

Several reports have demonstrated that mouse Cx3cr1 signaling promotes monocyte/macrophage survival. In agreement, we previously found that, in a mouse model of systemic candidiasis, genetic deficiency of Cx3cr1 resulted in increased mortality and impaired tissue fungal clearance associated with dec...

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Vydáno v:JCI Insight
Hlavní autoři: Collar, Amanda L., Swamydas, Muthulekha, O’Hayre, Morgan, Sajib, Md Sanaullah, Hoffman, Kevin W., Singh, Satya P., Mourad, Ahmad, Johnson, Melissa D., Ferre, Elise M.N., Farber, Joshua M., Lim, Jean K., Mikelis, Constantinos M., Gutkind, J. Silvio, Lionakis, Michail S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5821174/
https://ncbi.nlm.nih.gov/pubmed/29415879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.95417
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