Effect of early embryonic deletion of huntingtin from pyramidal neurons on the development and long-term survival of neurons in cerebral cortex and striatum

We evaluated the impact of early embryonic deletion of huntingtin (htt) from pyramidal neurons on cortical development, cortical neuron survival and motor behavior, using a cre-loxP strategy to inactivate the mouse htt gene (Hdh) in emx1-expressing cell lineages. Western blot confirmed substantial h...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Neurobiol Dis
Egile Nagusiak: Dragatsis, I., Dietrich, P., Ren, H., Deng, Y.P., Del Mar, N, Wang, H.B., Johnson, I.M., Jones, K.R., Reiner, A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5821111/
https://ncbi.nlm.nih.gov/pubmed/29274742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2017.12.015
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