Loss of p21 promoted tumorigenesis in the background of telomere dysfunctions induced by TRF2 and Wrn deficiency

Werner syndrome (WS) is a rare autosomal recessive progeria disease with genetic instability/cancer predisposition, thus a good model in understanding aging related carcinogenesis. Telomere dysfunction induced cellular senescence is essential in the manifestation of the WS phenotype. Our previous da...

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Detalhes bibliográficos
Publicado no:Int J Biol Sci
Main Authors: Si, Xiaoyu, Shao, Chihao, Li, Jing, Jia, Shuting, Tang, Wenru, Zhang, Jihong, Yang, Julun, Wu, Xiaoming, Luo, Ying
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5821038/
https://ncbi.nlm.nih.gov/pubmed/29483835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.23477
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